| Date | Home | Away | Result |
|---|---|---|---|
| 14/09/25 00:30 | New England Revolution | Toronto FC | 1-1 |
| 14/09/25 00:30 | CF Montreal | St. Louis City SC | 0-2 |
| 14/09/25 00:30 | Cincinnati FC | Nashville SC | 2-1 |
| 14/09/25 00:30 | D.C. United | Orlando City | 1-1 |
| 14/09/25 00:30 | Charlotte FC | Inter Miami CF | 3-0 |
| 14/09/25 00:30 | Atlanta United FC | Columbus Crew | 4-5 |
| 14/09/25 01:40 | FC Dallas | Austin FC | 3-0 |
| 14/09/25 01:40 | Seattle Sounders | Los Angeles Galaxy | 2-2 |
| 14/09/25 01:40 | San Jose Earthquakes | Los Angeles FC | 2-4 |
| 14/09/25 01:40 | Chicago Fire | New York City FC | 1-3 |
| 14/09/25 02:30 | Real Salt Lake | Sporting Kansas City | 2-1 |
| 14/09/25 02:30 | Colorado Rapids | Houston Dynamo | 2-1 |
| 14/09/25 02:35 | Vancouver Whitecaps | Philadelphia Union | 7-0 |
| 14/09/25 03:30 | San Diego FC | Minnesota United FC | 1-3 |
| 14/09/25 03:30 | Portland Timbers | New York Red Bulls | 2-1 |
| 17/09/25 00:30 | Inter Miami CF | Seattle Sounders | --- |