| Date | Home | Away | Result |
|---|---|---|---|
| 26/04/25 19:30 | Toronto FC | New York City FC | 0-1 |
| 26/04/25 19:30 | Cincinnati FC | Sporting Kansas City | 2-1 |
| 26/04/25 21:30 | Philadelphia Union | D.C. United | 3-0 |
| 26/04/25 21:30 | New York Red Bulls | CF Montreal | 1-0 |
| 27/04/25 00:15 | Orlando City | Atlanta United FC | 3-0 |
| 27/04/25 00:30 | San Diego FC | Real Salt Lake | 1-3 |
| 27/04/25 00:30 | Columbus Crew | San Jose Earthquakes | 2-1 |
| 27/04/25 00:30 | Charlotte FC | New England Revolution | 0-1 |
| 27/04/25 01:30 | Houston Dynamo | Austin FC | 2-0 |
| 27/04/25 01:30 | Nashville SC | Chicago Fire | 7-2 |
| 27/04/25 02:30 | Colorado Rapids | Seattle Sounders | 1-1 |
| 27/04/25 20:00 | Minnesota United FC | Vancouver Whitecaps | 1-3 |
| 27/04/25 22:00 | Inter Miami CF | FC Dallas | 3-4 |
| 28/04/25 00:00 | Los Angeles FC | St. Louis City SC | 2-2 |
| 28/04/25 02:00 | Los Angeles Galaxy | Portland Timbers | 2-4 |